Dr. Javier Barallobre-Barreiro
Javier Barallobre-Barreiro is a Molecular Biologist by training and the main focus of his research is the biology of cardiac extracellular matrix. During his PhD (2011, University of A Coruña, Spain), he developed in collaboration with Prof Manuel Mayr’s group (King’s College London) an approach study for the first time cardiac extracellular matrix remodeling using mass spectrometry. Javier joined King’s in 2011 as a Postdoctoral Researcher to continue with the same line of investigation. He improved the available strategies to study the cardiovascular extracellular matrix and investigated the role of extracellular matrix protein fragmentation in cardiac disease. In 2016 he was awarded a Career Establishment Fellowship at King’s, and in 2019 he obtained a British Heart Foundation Intermediate Basic Science Fellowship, focused on the investigation of the roles of extracellular proteases and proteoglycan remodeling using preclinical models of heart failure and clinical samples.
Education
| 2001-2006 | BSc, Universidad de A Coruna |
| 2007-2011 | PhD, CHU A Coruña, Spain |
Present Appointment
| 2019- | BHF Intermediate Basic Science Research Fellow, Cardiovascular Division, King’s College London, London, UK |
Previous Appointment
| 2016-2019 | Career Establishment Fellow Cardiovascular Division, King’s College University, London, UK |
| 2011-2016 | Research Associate Cardiovascular Division, King’s College London, London, UK |
Website
| www.cardio-research.com |
Latest Conferences Attended
| 1) The ISHR XXII World Congress, 18-21 April, 2016, Buenos Aires, Argentina Poster Presentation: Barallobre-Barreiro J et al. Glycoprotemics reveals decorin fragments with anti-myostatin activity in human atrial fibrillation.2) ESC Congress 2015, 29 August – 02 September 2015, London, UK Oral Presentation: Glycoproteomics analysis of cardiac extracellular matrix reveals the presence of decorin fragments with anti-myostatin and anti-fibrotic activity. J Barallobre-Barreiro, SK Gupta, X Yin, M Chong, M Jahangiri, R Viner, A Kichler, T Thum, J Heineke, M Mayr. *Mini-Oral session diploma winner. 3) Heart Failure Winter Research Meeting 21-24 January 2015, Les Diablerets, Swittzerland 4) International Symposium on Recent Advances in HF. 15-16 September, 2014, London, UK 5) Matrix Biology Europe Conference, June 21-24, 2014, Rotterdam, The Netherlands b) Poster presentation: Proteomic profiling of the human venous extracellular matrix reveals a role for mast cell proteases in the pathogenesis of varicose veins. 6) Proteoglycans 2013, August 25-29, 2013 Frankfurt/Main, Germany 7) The ISHR XXI World Congress, June 30 – July 4, 2013 in San Diego, California, USA 8) EuPA 2012 Scientific Congress 9 – 12 July 2012, Glasgow, UK |
Publications
| 1 | Theofilatos K, Stojkovic S, Hasman M, van der Laan SW, Baig F, Barallobre-Barreiro J, Schmidt LE, Yin S, Yin X, Burnap S, Singh B, Popham J, Harkot O, Kampf S, Nackenhorst MC, Strassl A, Loewe C, Demyanets S, Neumayer C, Bilban M, Hengstenberg C, Huber K, Pasterkamp G, Wojta J, Mayr M. Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes. Circulation Research. 2023 133(7) : 542-558. [Full Text] [PubMed] [DOI] |
| 2 | Ragone I, Barallobre-Barreiro J, Takov K, Theofilatos K, Yin X, Schmidt LE, Domenech N, Crespo-Leiro MG, van der Voorn SM., Vink A, van Veen TA.B., Bödör C, Merkely B, Radovits T, Mayr M. SERCA2a Protein Levels Are Unaltered in Human Heart Failure. Circulation. 2023 148(7) : 613–616. [Full Text] [PubMed] [DOI] |
| 3 | Duregotti E, Reumiller CM, Mayr U, Hasman M, Schmidt LE, Burnap SA, Theofilatos K, Barallobre-Barreiro J, Beran A, Grandoch M, Viviano A, Jahangiri M, Mayr M. Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity. Nature communications. 2022 13(1) : 7269. [Full Text] [PubMed] [DOI] |
| 4 | Reed E, Fellows A, Lu R, Rienks M, Schmidt L, Yin X, Duregotti E, Brandt M, Krasemann S, Hartmann K, Barallobre-Barreiro J, Addison O, Cuello F, Hansen A, Mayr M. Extracellular Matrix Profiling and Disease Modelling in Engineered Vascular Smooth Muscle Cell Tissues. Matrix biology plus. 2022 16 : 100122. [Full Text] [PubMed] [DOI] |
| 5 | Barallobre-Barreiro J, Radovits T, Fava M, Mayr U, Lin WY, Ermolaeva E, Martínez-López D, Lindberg EL, Duregotti E, Daróczi L, Hasman M, Schmidt LE, Singh B, Lu R, Baig F, Siedlar AM, Cuello F, Catibog N, Theofilatos K, Shah AM, Crespo-Leiro MG, Doménech N, Hübner N, Merkely BP, Mayr M. The Extracellular Matrix in Heart Failure: The Role of Adamts5 In Proteoglycan Remodelling. Circulation. 2021 : . [Full Text] [PubMed] [DOI] |
| 6 | Mayer L, Pechlaner R, Barallobre-Barreiro J, Boehme C, Toell T, Lynch M, Yin X, Willeit J, Gizewski ER, Perco P, Ratzinger G, Kiechl S, Mayr M, Knoflach M. Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection. Neurology. 2020 95(15) : e2047-55. [Full Text] [PubMed] [DOI] |
| 7 | Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, Fecher-Trost C, Reil JC, Linz B, Ruf S, Hübschle T, Maak C, Böhm M, Sadowski T, Linz D. Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry. 2020 295(36) : 12605-12617. [Full Text] [PubMed] [DOI] |
| 8 | Barallobre-Barreiro J, Loeys B, Mayr M, Rienks M, Verstraeten A, Kovacic JC. Extracellular Matrix in Vascular Disease, Part 2/4 JACC Focus Seminar. J Am Coll Cardiol. 2020 5, 75(17) : 2189-2203. [Full Text] [PubMed] [DOI] |
| 9 | Yin X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M.. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.. Arterioscler Thromb Vasc Biol.. 2019 39(9) : 1859-1873. [Full Text] [PubMed] [DOI] |
| 10 | Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Singh B, Sorensen N, Neumann JT, Zeller T, Westermann D.. Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circulation research. 2019 Epub : . [Full Text] [PubMed] [DOI] |
| 11 | Rienks M, Barallobre-Barreiro J, Mayr M. The Emerging Role of the ADAMTS Family in Vascular Diseases. Circ Res. 2018 123 : 1279-1281. [Full Text] [PubMed] [DOI] |
| 12 | Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight. 2018 3 : e123335. [Full Text] [PubMed] [DOI] |
| 13 | Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X, Jahangiri M, Mayr M. Role of ADAMTS (A Disintegrin and Metalloproteinase With Thrombospondin Motifs)-5 in Aortic Dilatation and Extracellular Matrix Remodeling. Arterioscler Thromb Vasc Biol. 2018 38 : 1537-1548. [Full Text] [PubMed] [DOI] |
| 14 | Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski K, Gasior P, Buszman PP, Buszman PE, Jahangiri M, Shanahan C, Hill JM, Mayr M. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018 137 : 166-183. [Full Text] [PubMed] [DOI] |
| 15 | Barallobre-Barreiro J, Baig F, Fava M, Yin X, Mayr M. Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry. J Vis Exp. 2017 122 : . [Full Text] [PubMed] [DOI] |
| 16 | Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017 4 : 1546-1560. [Full Text] [PubMed] [DOI] |
| 17 | Barallobre-Barreiro J, Lynch M, Yin X, Mayr M. Systems Biology - Opportunities and Challenges: The Application of Proteomics to Study the Cardiovascular Extracellular Matrix. Cardiovasc Res. 2016 112 : 626-636. [Full Text] [PubMed] [DOI] |
| 18 | Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 134 : 817-832. [Full Text] [PubMed] [DOI] |
| 19 | Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier D, Albadawi H, Jahangiri M, Porter K, Watkins M, Misra S, Stoughton J, Mayr M. Extracellular Matrix Remodeling in Response to Venous Hypertension: Proteomics of Human Varicose Veins. Cardiovasc Res. 2016 110 : 419-430. [Full Text] [PubMed] [DOI] |
| 20 | Fernandez-Caggiano M, Schröder E, Cho HJ, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P. Oxidant-induced interprotein disulfide formation in cardiac DJ-1 occurs via an interaction with peroxiredoxin 2. J Biol Chem. 2016 291 : 10399-10410. [Full Text] [PubMed] [DOI] |
| 21 | Lynch M, Barallobre-Barreiro J, Jahangiri M, Mayr M. Vascular proteomics in metabolic and cardiovascular diseases. J Intern Med. 2016 280 : 325-338. [Full Text] [PubMed] [DOI] |
| 22 | Fernandez-Caggiano M, Prysyazhna O, Barallobre-Barreiro J, Calvi Ncarono Santos R, Aldama Lopez G, Crespo-Leiro MG, Eaton P, Doménech N. Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue viability. Mol Cell Proteomics. 2015 Epub : Ahead of Print. [PubMed] |
| 23 | Barallobre-Barreiro J, Mayr M. Affinity proteomics for phosphatase interactions in atrial fibrillation. J Am Coll Cardiol. 2015 65 : 174-176. [Full Text] [PubMed] [DOI] |
| 24 | Zampetaki A, Attia RQ, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley S, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M. Role of miR-195 in Aortic Aneurysmal Disease. Circ Res. 2014 115 : 857-866. [Full Text] [PubMed] [DOI] |
| 25 | Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley S, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular Matrix Secretion by Cardiac Fibroblasts: Role of microRNA-29b and microRNA-30c. Circ Res. 2013 113 : 1138-1147. [Full Text] [PubMed] [DOI] |
| 26 | Barallobre-Barreiro J, Chung YL, Mayr M. Proteomics and metabolomics for mechanistic insights and biomarker discovery in cardiovascular disease. Rev Esp Cardiol. 2013 66 : 657-661. [Full Text] [PubMed] [DOI] |
| 27 | Barallobre-Barreiro J, Didangelos A, Yin X, Domönech N, Mayr M. A sequential extraction methodology for cardiac extracellular matrix prior to proteomics analysis. Methods Mol Biol. 2013 1005 : 215-223. [PubMed] [DOI] |
| 28 | Fernández-Caggiano M, Barallobre-Barreiro J, Rego-Pérez I, Crespo-Leiro MG, Paniagua MJ, Grillé Z, Blanco FJ, Doménech N. Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population. Mitochondrion. 2013 13 : 263-268. [PubMed] [DOI] |
| 29 | Stegemann C, Didangelos A, Barallobre-Barreiro J, Langley S, Mandal K, Jahangiri M, Mayr M. Proteomic Identification of Matrix Metalloproteinase Substrates in the Human Vasculature. Circ Cardiovasc Genet. 2013 6 : 106-117. [Full Text] [PubMed] [DOI] |
| 30 | Fernández-Caggiano M, Barallobre-Barreiro J, Rego-Pérez I, Crespo-Leiro MG, Paniagua MJ, Grillé Z, Blanco FJ, Doménech N. Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy. PLoS One. 2012 7 : e44128. [PubMed] [DOI] |
| 31 | Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann VO, Aldama-Lápez G, Shah AM, Doménech N, Mayr M. Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia-Reperfusion Injury. Circulation. 2012 125 : 789-802. [Full Text] [PubMed] [DOI] |
| 32 | Moscoso I, Rodriguez-Barbosa JI, Barallobre-Barreiro J, Anon P, Domenech N. Immortalization of bone marrow-derived porcine mesenchymal stem cells and their differentiation into cells expressing cardiac phenotypic markers. J Tissue Eng Regen Med. 2012 6 : 655-665. [PubMed] [DOI] |
| 33 | Barallobre-Barreiro J, de Ilárduya OM, Moscoso I, Calviño-Santos R, Aldama G, Centeno A, López-Pelaez E, Doménech N. Gene expression profiles following intracoronary injection of mesenchymal stromal cells using a porcine model of chronic myocardial infarction. Cytotherapy. 2011 13 : 407-418. [PubMed] |
| 34 | Barallobre-Barreiro J, de Ilárduya OM, Moscoso I, Calviño R, Aldama G, López-Peláez E, Centeno A, Doménech N. Comparison of gene expression profiles in a porcine infarct model after intracoronary, transthoracic, or transendocardiac injection of heterologous bone marrow mesenchymal cells. Transplant Proc.. 2009 41 : 2279-2281. [PubMed] |